The Power of Antioxidants

Did you know? Molecular hydrogen acts like an antioxidant in the body! Antioxidants help remove free radicals which can reduce inflammation.

A fresh squeezed orange is about -100 to -150 ORP, which is its oxidation reduction potential.

A single glass of Kangen water from the newest flagship model, the LeveLuk K8, is 6X more potent in antioxidants than a fresh squeezed orange, at about -600 ORP.

If you drink a glass of orange juice for the health benefits imagine what a few glasses of hydrogen rich Kangen water can do for you!

The human body is more than 70% water.

The quality of our water matters and has the potential to dramatically improve our health!

You can find many published studies on the effects of molecular hydrogen when consumed in water below.

-Comparison to reverse osmosis and Berkey filter found at the bottom.

This is a wealth of information so please feel free to reach out for assistance.

MOLECULAR HYDROGEN & ERW GENERAL STUDIES

• Beneficial biological effects and the underlying mechanisms of molecular hydrogen – comprehensive review of 321 original articles

• Comprehensive Review Study on the Clinical Effects of Hydrogen

• Molecular hydrogen as a novel antioxidant: overview of the advantages of hydrogen for medical applications

• Molecular Hydrogen as an Emerging Therapeutic Medical Gas for Neurodegenerative and Other Diseases

• Molecular hydrogen as a preventive and therapeutic medical gas: initiation, development and potential of hydrogen medicine

• Molecular hydrogen: a therapeutic antioxidant and beyond

• The evolution of molecular hydrogen: A noteworthy potential therapy with clinical significance

• Hydrogen rich water in oral pathology (2018)

• Recent Advances in Studies of Molecular Hydrogen against Sepsis (2019)

• Molecular hydrogen affects body composition, metabolic profiles, and mitochondrial function in middle-aged overweight women (2018)

• The Efficacy and Tolerability of Electrolyzed Oxidized Water in Treating Mild to Moderate Acne

• Hydrogen-Rich Saline as an Innovative Therapy for Cataract

• Effects of Electrolyzed Reduced Water (ERW) on NF-κB/iNOS Pathway in U937 Cell Line under Altered Redox State

• Effectiveness of hydrogen rich water on antioxidant status of subjects with potential metabolic syndrome-an open label pilot study

• Effects of alkaline-electrolyzed and hydrogen-rich water, in a high-fat-diet nonalcoholic fatty liver (2019)

• The Effects of 24-Week, High-Concentration Hydrogen-Rich Water on Body Composition, Blood Lipid Profiles and Inflammation Biomarkers in Men and Women with Metabolic Syndrome (2020)

• Effect of hydrogen-rich water on the Nrf2/ARE signaling pathway in rats with myocardial ischemia-reperfusion injury (2019)

• Hydrogen water alleviates paraquat-induced lung fibroblast injury in vitro by enhancing Nrf2 expression (2020)

• Hydrogen Attenuates Allergic Inflammation by Reversing Energy Metabolic Pathway Switch (2020)

• Molecular hydrogen alleviates motor deficits and muscle degeneration (2017)

• Hydrogen water alleviates obliterative airway disease (2020)

GENE EXPRESSION AND MODULATION

• Preventive and Therapeutic Application of Molecular Hydrogen in Situations With Excessive Production of Free Radicals

• Molecular hydrogen modulates gene expression via histone modification and induces the mitochondrial unfolded protein response

• Molecular hydrogen inhibits lipopolysaccharide/interferon γ-induced nitric oxide production through modulation of signal transduction in macrophages

• Molecular hydrogen may enhance the production of testosterone hormone in male infertility through hormone signal modulation and redox balance

• Modulation of the oxidative plasmatic state in gastroesophageal reflux disease with the addition of rich water molecular hydrogen: A new biological vision

• Molecular hydrogen regulates gene expression by modifying the free radical chain reaction-dependent generation of oxidized phospholipid mediators

• Molecular hydrogen stimulates the gene expression of transcriptional coactivator PGC-1α to enhance fatty acid metabolism

• Molecular Hydrogen Reduces LPS-Induced Neuroinflammation and Promotes Recovery from Sickness Behaviour

• Molecular Hydrogen Improves Obesity and Diabetes by Inducing Hepatic FGF21 and Stimulating Energy Metabolism

• Molecular hydrogen upregulates heat shock response and collagen biosynthesis, and downregulates cell cycles: meta-analyses of gene expression profiles

ATHLETES

• Improves heart function: Hydrogen Inhalation is Superior to Mild Hypothermia in Improving Cardiac Function and Neurological Outcome in an Asphyxial Cardiac Arrest Model of Rats

• Increased ATP production: Hydrogen-supplemented drinking water protects cardiac allografts from inflammation-associated deterioration

• Increased ATP production: Molecular Hydrogen in Drinking Water Protects against Neurodegenerative Changes Induced by Traumatic Brain Injury

• Increased ATP production: Stimulation of human damaged sperm motility with hydrogen molecule

• Increased Metabolism: Molecular hydrogen stimulates the gene expression of transcriptional co-activator PGC-1α to enhance fatty acid metabolism

• Post recovery: Is molecular hydrogen beneficial to enhance post-exercise recovery in female athletes

• Prevents cognitive decline: Molecular Hydrogen and its Potential Application in Therapy of Brain Disorders

• Prevents Muscle fatigue/reduces lactic acid: Effects of drinking hydrogen-rich water on muscle fatigue caused by acute exercise in elite athletes  

• Selective antioxidant: Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals

• Sport Medicine: Molecular hydrogen in sports medicine: new therapeutic perspectives

• Sport related injuries: Effectiveness of oral and topical hydrogen for sports-related soft tissue injuries

• Acute hydrotherapy with super-saturated hydrogen-rich water for ankle sprain in a professional athlete (2020)

CANCER

• Hydrogen-dissolved water inhibits growth of human tongue carcinoma cells

• Hydrogen–water enhances 5-fluorouracil-induced inhibition of colon cancer

• Hyperbaric hydrogen therapy: A possible treatment for cancer

• Molecular hydrogen alleviates nephrotoxicity induced by an anti-cancer drug cisplatin without compromising anti-tumor activity in mice

• Neutral pH hydrogen-enriched electrolyzed water achieves tumor-preferential clonal growth inhibition over normal cells and tumor invasion inhibition concurrently with intracellular oxidant repression

• Suppressive effects of electrochemically reduced water on matrix metalloproteinase-2 activities and in vitro invasion of human fibrosarcoma HT1080 cells

• Telomere Shortening in Cancer Cells by Electrolyzed-Reduced Water:

• Inhibitory Effect of Electrolyzed Reduced Water on Tumor Angiogenesis

• Enhanced induction of mitochondrial damage and apoptosis in human leukemia HL-60 cells due to electrolyzed-reduced water and glutathione.

• Electrolyzed Reduced Water Induces Differentiation in K-562 Human Leukemia Cells

• Electrochemically Reduced Water Delays Mammary Tumors Growth in Mice and Inhibits Breast Cancer Cells Survival (2018)

• Hydrogen gas therapy induced shrinkage of metastatic gallbladder cancer (2019)

• Anti-inflammatory and antitumor action of hydrogen via reactive oxygen species (2018)

• Hydrogen inhibits endometrial cancer growth via a ROS/NLRP3/caspase-1/GSDMD-mediated pyroptotic pathway (2020)

• Hydrogen Gas in Cancer Treatment (2019)

  RADIOTHERAPY

• Effects of drinking hydrogen-rich water on the quality of life of patients treated with radiotherapy for liver tumors

• Hydrogen as a new class of radioprotective agent

• Molecular hydrogen and radiation protection

• The hypothesis of an effective safe and novel radioprotective agent

• The healing effect of hydrogen-rich water on acute radiation-induced skin injury (2019)

PH LEVEL EFFECT ON CANCER

• Bicarbonate Increases Tumor pH and Inhibits Spontaneous Metastases

• Microenvironmental pH is a key factor for exosome traffic in tumor cells.

• Acid-mediated tumor invasion: a multidisciplinary study.

• Out of Warburg effect: An effective cancer treatment targeting the tumor specific metabolism and dysregulated pH

PARKINSON

• Drinking hydrogen water and intermittent hydrogen gas exposure, but not lactulose or continuous hydrogen gas exposure, prevent 6-hydorxydopamine-induced Parkinson’s disease in rats

• Hydrogen in Drinking Water Reduces Dopaminergic Neuronal Loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine Mouse Model of Parkinson’s Disease

• Hydrogen therapy: from mechanism to cerebral diseases

• Pilot study of H2 therapy in Parkinson’s disease: A randomized double-blind placebo-controlled trial

• Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson’s disease

• Therapeutic Effects of Hydrogen in Animal Models of Parkinson’s Disease

• A randomized double-blind multi-center trial of hydrogen water for Parkinson's disease

• Parkinson's disease may be due to failure of melanin in the Substantia Nigra to produce molecular hydrogen from dissociation of water, to protect the brain from oxidative stress.

• Positive effect of an electrolyzed reduced water on gut permeability, fecal microbiota and liver in an animal model of Parkinson's disease (2019)

KIDNEY DISEASES

• Hydrogen: another gas with therapeutic potential

• Hydrogen-Rich Saline Promotes the Recovery of Renal Function after Ischemia/Reperfusion Injury in Rats via Anti-apoptosis and Anti-inflammation

• Hydrogen-rich water inhibits glucose and α,β -dicarbonyl compound-induced reactive oxygen species production in the SHR.Cg-Lepr/NDmcr rat kidney

• Inhalation of Hydrogen Gas Is Beneficial for Preventing Contrast-Induced Acute Kidney Injury in Rats

• Intake of water with high levels of dissolved hydrogen (H2) suppresses ischemia-induced cardio-renal injury in Dahl salt-sensitive rats

• The hydrogen molecule as antioxidant therapy: clinical application in hemodialysis and perspectives

• The melamine excretion effect of the electrolyzed reduced water in melamine-fed mice

STROKE

• Hydrogen improves neurological function through attenuation of blood–brain barrier disruption in spontaneously hypertensive stroke-prone rats

• Lactulose: an effective preventive and therapeutic option for ischemic stroke by production of hydrogen

• Potential application of hydrogen in traumatic and surgical brain injury, stroke and neonatal hypoxia-ischemia

• The hydrogen highway to reperfusion therapy

HAEMODIALYSIS

• Electrolysed-reduced water dialysate improves T-cell damage in end-stage renal disease patients with chronic haemodialysis

• Reduced hemodialysis-induced oxidative stress in end-stage renal disease patients by electrolyzed reduced water

• Electrolyzed-reduced water reduced hemodialysis-induced erythrocyte impairment in end-stage renal disease patients

• Biological effects of electrolyzed water in hemodialysis

• Possible clinical effects of molecular hydrogen (H2) delivery during hemodialysis in chronic dialysis patients

• Less-oxidative hemodialysis solution rendered by cathode-side application of electrolyzed water

• A novel bioactive haemodialysis system using dissolved dihydrogen (H2) produced by water electrolysis

• The hydrogen molecule as antioxidant therapy: clinical application in hemodialysis and perspectives

OXIDATIVE STRESS

• Oxidative stress

• Oxidative Stress and Antioxidant Defense

• Oxidative stress in health and disease: the therapeutic potential of Nrf2 activation

• Oxidative stress in human diseases

• Oxidative Stress and Neurodegenerative Diseases: A Review of Upstream and Downstream Antioxidant Therapeutic Options

• Oxidative stress and psychological disorders

• A New Approach for the Prevention and Treatment of Cardiovascular Disorders. Molecular Hydrogen Significantly Reduces the Effects of Oxidative Stress (2019)

• Molecular hydrogen is a novel antioxidant to efficiently reduce oxidative stress with potential for the improvement of mitochondrial diseases.

• Open-label trial and randomized, double-blind, placebo-controlled, crossover trial of hydrogen-enriched water for mitochondrial and inflammatory myopathies

• Preventive and therapeutic application of molecular hydrogen in situations with excessive production of free radicals

• The preventive and therapeutic effects of molecular hydrogen in ocular diseases and injuries where oxidative stress is involved

• Electrolyzed-reduced water scavenges active oxygen species and protects DNA from oxidative damage

• Review and prospect of the biomedical effects of hydrogen

• Molecular hydrogen: a preventive and therapeutic medical gas for various diseases.

• Promising novel therapy with hydrogen gas for emergency and critical care medicine

• Does H2 Alter Mitochondrial Bioenergetics via GHS-R1α Activation?

• Fundamental Insight into the Methodology of Hydrogen Water in Biological Studies

• Clinical Effects of Hydrogen Administration: From Animal and Human Diseases to Exercise Medicine

• The Clinical Application of Hydrogen as a Medical Treatment

• Therapeutic Effects of Hydrogen on Different Diseases

• A hypothesis on chemical mechanism of the effect of hydrogen

• Reduced Water for Prevention of Diseases

• Electrolyzed–Reduced Water Scavenges Active Oxygen Species and Protects DNA from Oxidative Damage

• Hydrogen gas alleviates oxygen toxicity by reducing hydroxyl radical levels in PC12 cells (2017)

• Preventive Effects of Drinking Hydrogen-Rich Water on Gingival Oxidative Stress and Alveolar Bone Resorption (2017)

  HIGH RANKING STUDIES

• Consumption of water containing over 3.5 mg of dissolved hydrogen could improve vascular endothelial function

• Effects of hydrogen-rich water on aging periodontal tissues in rats

• Effects of hydrogen-rich water on depressive-like behavior in mice

• Effect of Hydrogen-Rich Water on Oxidative Stress, Liver Function, and Viral Load in Patients with Chronic Hepatitis B

• Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals

• Hydrogen-rich water decreases serum LDL-cholesterol levels and improves HDL function in patients with potential metabolic syndrome

• Hyperbaric hydrogen therapy: a possible treatment for cancer

• Molecular hydrogen regulates gene expression by modifying the free radical chain reaction-dependent generation of oxidized phospholipid mediators

• Molecular hydrogen stimulates the gene expression of transcriptional coactivator PGC-1α to enhance fatty acid metabolism

• Neuroprotective Effect of Hydrogen-Rich Saline against Neurologic Damage and Apoptosis in Early Brain Injury following Subarachnoid Hemorrhage: Possible Role of the Akt/GSK3β Signaling Pathway

• Oral ‘hydrogen water’ induces neuroprotective ghrelin secretion in mice

• Pilot study of H2 therapy in Parkinson’s disease: A randomized double-blind placebo-controlled trial 

• The hydrogen highway to reperfusion therapy

• Hydrogen-rich water improves neurological functional recovery in experimental autoimmune

ARTHRITIS

• Consumption of water containing a high concentration of molecular hydrogen reduces oxidative stress and disease activity in patients with rheumatoid arthritis: an open-label pilot study

• Molecular hydrogen decelerates rheumatoid arthritis progression through inhibition of oxidative stress

• Molecular Hydrogen: New Antioxidant and Anti-inflammatory Therapy for Rheumatoid Arthritis and Related Diseases

• Molecular hydrogen protects chondrocytes from oxidative stress and indirectly alters gene expressions through reducing peroxynitrite derived from nitric oxide

• Molecular hydrogen suppresses activated Wnt/β-catenin signaling

• Therapeutic efficacy of infused molecular hydrogen in saline on rheumatoid arthritis: a randomized, double-blind, placebo-controlled pilot study

• Alkaline Mineral Supplementation Decreases Pain in Rheumatoid Arthritis Patients

PSORIASIS

• Positive effects of hydrogen-water bathing in patients of psoriasis and parapsoriasis

• Improvement of psoriasis-associated arthritis and skin lesions by treatment with molecular hydrogen: A report of three cases

• Oxidant/Antioxidant Status in Patients with Psoriasis

• Role of cellular oxidative stress and cytochrome c in the pathogenesis of psoriasis

• Aquaporin-3-mediated hydrogen peroxide transport is required for NF-κB signalling in keratinocytes and development of psoriasis

HEART DISEASE

• Are the effects of alpha-glucosidase inhibitors on cardiovascular events related to elevated levels of hydrogen gas in the gastrointestinal tract?

• Breathing nitric oxide plus hydrogen gas reduces ischemia-reperfusion injury and nitrotyrosine production in murine heart

• Cardioprotective Effect of Hydrogen-rich Saline on Isoproterenol-induced Myocardial Infarction in Rats

• Consumption of hydrogen water prevents atherosclerosis in apolipoprotein E knockout mice

• H2 Gas Improves Functional Outcome After Cardiac Arrest to an Extent Comparable to Therapeutic Hypothermia in a Rat Model

• Hydrogen Inhalation is Superior to Mild Hypothermia in Improving Cardiac Function and Neurological Outcome in an Asphyxial Cardiac Arrest Model of Rats

• Hydrogen gas protects against serum and glucose deprivation‑induced myocardial injury in H9c2 cells through activation of the NF‑E2‑related factor 2/heme oxygenase 1 signaling pathway

• Hydrogen (H2) Inhibits Isoproterenol-Induced Cardiac Hypertrophy via Antioxidative Pathways

• Hydrogen-Rich Saline Attenuates Lipopolysaccharide-Induced Heart Dysfunction by Restoring Fatty Acid Oxidation in Rats by Mitigating C-Jun N-Terminal Kinase Activation

• Treatment with hydrogen molecule attenuates cardiac dysfunction in streptozotocin-induced diabetic mice

NEUROLOGICAL DISORDERS

• Molecular Hydrogen as a Neuroprotective Agent

• Hydrogen-rich water for improvements of mood, anxiety, and autonomic nerve function in daily life (2018)

• Molecular hydrogen in the treatment of acute and chronic neurological conditions: mechanisms of protection and routes of administration (2017)

• Hydrogen therapy: from mechanism to cerebral diseases

• Hydrogen-rich water attenuates amyloid β-induced cytotoxicity through upregulation of Sirt1-FoxO3a by stimulation of AMP-activated protein kinase in SK-N-MC cells

• Molecular hydrogen in drinking water protects against neurodegenerative changes induced by traumatic brain injury

• Molecular hydrogen in the treatment of acute and chronic neurological conditions: mechanisms of protection and routes of administration

• Effects of hydrogen-rich water on depressive-like behavior in mice

• Electrolyzed-reduced water mitigates amyloid beta toxicity via DAF-16 in C. elegans

• Hydrogen as a novel hypothesized emerging treatment for oxidative stress in autism

• Hydrogen-rich saline improves memory function in a rat model of amyloid-beta-induced Alzheimer’s disease by reduction of oxidative stress

• Hydrogen-rich water attenuates amyloid β-induced cytotoxicity through upregulation of Sirt1-FoxO3a by stimulation of AMP-activated protein kinase in SK-N-MC cells

• Molecular hydrogen: an overview of its neurobiological effects and therapeutic potential for bipolar disorder and schizophrenia

• Molecular Hydrogen Reduces LPS-Induced Neuroinflammation and Promotes Recovery from Sickness Behaviour in Mice

• Physical exercise and intermittent administration of lactulose may improve autism symptoms through hydrogen production

• Treatment with Hydrogen-Rich Saline Delays Disease Progression in a Mouse Model of Amyotrophic Lateral Sclerosis

AUTISM

• Physical exercise and intermittent administration of lactulose may improve autism symptoms through hydrogen production

• Hydrogen-Rich Water Ameliorates Autistic-Like Behavioral Abnormalities

• Hydrogen as a novel hypothesized emerging treatment for oxidative stress in autism

• more personal testimonials

DIABETES

• Anti-diabetes effect of water containing hydrogen molecule and Pt nanoparticles

• Anti-Oxidative Water Improves Diabetes

• Effects of hydrogen-rich water on abnormalities in a SHR.Cg-Leprcp/NDmcr rat – a metabolic syndrome rat mode

• Hydrogen Improves Glycemic Control in Type1 Diabetic Animal Model by Promoting Glucose Uptake into Skeletal Muscle

• Molecular hydrogen improves obesity and diabetes by inducing hepatic FGF21 and stimulating energy metabolism in db/db mice

• Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance

• Suppressive effects of natural reduced waters on alloxan-induced apoptosis and type 1 diabetes mellitus

• Therapeutic effects of hydrogen saturated saline on rat diabetic model and insulin resistant model via reduction of oxidative stress

• Treatment with hydrogen molecule attenuates cardiac dysfunction in streptozotocin-induced diabetic mice

• Protective mechanism of reduced water against alloxan-induced pancreatic beta-cell damage

• Anti-diabetic effects of electrolyzed reduced water in streptozotocin-induced and genetic diabetic mice

• Preservative effect of electrolyzed reduced water on pancreatic beta-cell mass in diabetic db/db mice

• Subcutaneous injection of hydrogen gas is a novel effective treatment for type 2 diabetes (2018)

• Molecular Hydrogen Improves Obesity and Diabetes by Inducing Hepatic FGF21 and Stimulating Energy Metabolism

REFLUX DISEASE

• Potential benefits of pH 8.8 alkaline drinking water as an adjunct in the treatment of reflux disease

• Modulation of the oxidative plasmatic state in gastroesophageal reflux disease with the addition of rich water molecular hydrogen

• Dose-dependent inhibition of gastric injury by hydrogen in alkaline electrolyzed drinking water

IBS

• Effects of Alkaline-Reduced Drinking Water on Irritable Bowel Syndrome with Diarrhea: A Randomized Double-Blind, Placebo-Controlled Pilot Study

• Long-Term Potable Effects of Alkalescent Mineral Water on Intestinal Microbiota Shift and Physical Conditioning (2020)

REVERSE OSMOSIS RESEARCH

• Water in Hindu Mythology.

• Health Effects of the Removal of Substances Occurring Naturally in Drinking-water

• Guidelines on health aspects of water desalination

• Microscopic changes associated with water absorption

• Intake of highly demineralized water damage the rat gastrointestinal tract

• Health effects of long term consumption of water low in calcium, magnesium

• Distilled water for drinking?

• The Shocking Truth about Water

• Serum zinc and demineralized water

• Seizures and delirium in a trekker: the consequences of excessive water drinking

• Hyponatremic seizures among infants fed with commercial bottled drinking water

• Drinking water and cardiovascular disease

• Drinking water hardness and chronic degenerative diseases.

• Drinking water hardness and chronic degenerative diseases. Part I. Analysis of epidemiological research

• High significance of drinking water calcium and magnesium

• Components of drinking water and risk of cognitive impairment in the elderly

• Association of very low birth weight with calcium levels in drinking water

• Calcium and magnesium in drinking water and risk of death from colon cancer

• Calcium, magnesium, and nitrate in drinking water and gastric cancer mortality

• Magnesium deficiency and sudden death

• Sudden cardiac death rate in an area characterized by high incidence of coronary artery disease and low hardness of drinking water

• Variation in the mineral content of commercially available bottled waters: implication for health and disease

• Motor neuron disease on the Kii Peninsula of Japan

• Influence of Increasing the Calcium and Magnesium Content of the Drinking Water on Performance and Bone and Plasma Minerals

• Pancreatic cancer mortality and total hardness levels in Taiwan's drinking water.

• Rectal cancer mortality and total hardness levels in Taiwan’s drinking water

• Calcium and magnesium in drinking water and the risk of death from breast cancer

• Magnesium in drinking water in relation to morbidity and mortality from acute myocardial infarction

• National Institute of Public Health

• Changes in the mineral composition of food as a result of cooking in “hard“ and “soft“ waters

• Health Risks from drinking demeneralized water

• Surveillance for Waterborne Disease Outbreaks United States

• Nutritional factors in relation to heavy metal toxicants

• Chemical qualities of water that contribute to human health in a positive way

• Typhoid fever from water desalinized using reverse osmosis

• Bacterial colonization of reverse-osmosis water filtration units

• Gastrointestinal health effects associated with the consumption of drinking water produced by point-of-use domestic reverse-osmosis filtration units

• Guidelines for Drinking-water quality

Berkey vs Kangen demo